Chronic Myeloid Leukemia (CML)

Overview

CML is characterized by Philadelphia chromosome, BCR-ABL fusion.

Symptoms

• •Fatigue
• •Splenomegaly
• •Weight loss
• •Night sweats

Stages

Diagnosis

• ✓Blood count
• ✓BCR-ABL PCR
• ✓Bone marrow
• ✓FISH

Treatments

• →Imatinib
• →Dasatinib
• →Nilotinib
• →Stem cell transplant (rare)

Risk Factors