Gastrointestinal Stromal Tumor (GIST)

Overview

GIST is a sarcoma of the GI tract, driven by KIT or PDGFRA mutations.

Symptoms

• •Abdominal pain
• •GI bleeding
• •Early satiety
• •Mass

Stages

Diagnosis

• ✓CT abdomen
• ✓Endoscopy
• ✓Biopsy
• ✓KIT/PDGFRA testing

Treatments

• →Surgical resection
• →Imatinib (Gleevec)
• →Sunitinib
• →Regorafenib

Risk Factors