Mantle Cell Lymphoma

Overview

Mantle cell lymphoma has aggressive and indolent features, cyclin D1 overexpression.

Symptoms

• •Lymphadenopathy
• •GI symptoms
• •B symptoms
• •Splenomegaly

Stages

Diagnosis

• ✓Biopsy
• ✓IHC (cyclin D1+)
• ✓t(11;14)
• ✓PET-CT

Treatments

• →R-CHOP
• →Ibrutinib
• →Autologous stem cell transplant
• →BTK inhibitors

Risk Factors