Hemophilia

Overview

Hemophilia is X-linked bleeding disorder due to factor VIII (A) or IX (B) deficiency.

Symptoms

• •Joint bleeding
• •Muscle hematoma
• •Prolonged bleeding
• •Spontaneous bleeds (severe)

Stages

Diagnosis

• ✓aPTT ↑
• ✓FVIII/IX activity <40%
• ✓Genetic testing

Treatments

• →FVIII/IX concentrate
• →Prophylaxis
• →Emicizumab (A)

Risk Factors