Sickle Cell Disease

Overview

Sickle cell disease is inherited hemoglobinopathy causing RBC sickling, vaso-occlusion, hemolysis.

Symptoms

• •Pain crises
• •Anemia
• •Dactylitis
• •Stroke

Stages

Diagnosis

• ✓HbS on electrophoresis
• ✓Newborn screening
• ✓CBC (low Hb, high retic)

Treatments

• →Hydroxyurea
• →Transfusion
• →Pain management
• →BMT (cure)

Risk Factors